Roger Tine

University

Faculty of Medicine, Université Cheikh Anta Diop (University of Dakar), Senegal.

PhD Title

An integrated malaria control strategy including RDT, ACT, rectal Artesunate and IPTc, delivered by community health workers in Senegal.

Abstract

Introduction:

Several strategies have been developed to control malaria. However, at the operational level these strategies are not well integrated.

Objective:

To study mechanisms for an integrated malaria control strategy including ACT, Rectal artesunate and IPTc delivered by community health workers.

Methods Study area:

Senegalese rural area of Keur Socé. Children under 5 years with RDT confirmed malaria will be treated with artesunate-amodiaquine. Community health workers will administer the first treatment dose. Other doses will be given at home by parents. Adequate Clinical and Parasitological response at day 28 will be assessed. Children with severe malaria will receive 10mg/kg artesunate by rectal route and transferred at the health-post for intravenous quinine treatment. End points will include time to oral route, recovery, correct administration of rectal artesunate. During the transmission season, children under five years will receive 3 monthly doses of either Amodiaquine-SP or Mefloquine-Piperaquine. Community health workers will be randomised to deliver IPTc treatments. Children will be visited weekly for 3 months to mesure incidence of malaria attacks and incidence of adverse events. The impact of integrated strategies will be assessed by cross sectional survey before and after implementation. Indicators: Malaria parasite prevalence and malaria morbidity.