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Assessment of the efficacy, tolerability and ease of administration of, dihydroarthemisinin plus piperaquine and artesunate plus sulfamethoxypyrazine plus pyrimethamine compared to sulphadoxime-pyrimethamine for preventing malaria in Ghanaian children

Lead researcher: 
Margaret Kweku, Daniel Chandramohan and Health workers, Hohoe, Ghana

This study, which was completed in 2011,  showed that  dihydroartemisinin + piperaquine given once a day for three days and artesunate + sulphamethoxypyrazine (Co-arinate) given twice over 24 hours were both more effective than a single dose of sulphadoxine pyrimethamine in clearing asexual parasitaemia in young Ghanaian children and could, therefore, be suitable combinations for use in seasonal malaria chemoprevention.

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